Sin1 mediated
WebbSin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis The mechanistic target of rapamycin (mTOR) … Webb27 okt. 2013 · Sin1 phosphorylation suppresses mTORC2 kinase activity towards phosphorylating Akt in vitro. (a,b) HEK293T cells were transfected with the indicated Flag-tagged Sin1 constructs. At 36 h...
Sin1 mediated
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Webb31 jan. 2024 · Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc. ... WebbSin1 (stress-activated protein kinase-interacting protein) as an essential component of mTORC2 (mammalian target of rapamycin complex 2) is required for cell proliferation …
Webb3 okt. 2024 · Particularly, knockdown SLC7A11 by siRNA showed that SLC7A11-mediated cystine uptake is responsible for activating mTORC2. Mechanistically, we found that p38 is activated in response to cystine stimulation, and co-immunoprecipitation experiments suggested that p38 regulated the assembly of components within mTORC2 by mediating … Webb19 nov. 2024 · S ty1/Spc1- in teracting protein 1 (Sin1), also known as mitogen-activated protein kinase ( MAPK) a ssociated p rotein (MAPKAP)1, was first identified in 1999 in fission yeast Schizosaccharomyces pombe as an adaptor protein interacting with Sty1 (also known as Spc1), a member of the eukaryotic stress-activated protein kinase …
WebbThe pathological Sin1-R81T mutation exhibited elevated oncogenic activity in part by bypassing Sin1 phosphorylation-mediated negative regulation of Akt-pS473. (a–c) … Webb14 nov. 2024 · Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2 November 2024 Journal of Molecular Cell Biology 11 (2) DOI: 10.1093/jmcb/mjy065 License CC BY 4.0...
Webb13 aug. 2010 · Here we show that Sin1, an essential component of mTOR complex 2 (mTORC2), regulates B cell development. Sin1 deficiency results in increased IL-7 …
Webb11 aug. 2015 · SIN1 phosphorylation mediates a positive feedback loop between Akt and mTORC2 Summary The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is known about the regulation of mTORC2 itself. flo gas bottle suppliersWebbThe cytotoxicity of fresh SIN-1 is dramatically suppressed in a basal medium (Hanks balanced salt), suggesting that the cytotoxicity of fresh SIN-1 also requires components … great lawyers without formal legal educationWebb21 feb. 2024 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more) (Over 39 million articles, preprints and more) great laxey mine railway locomotivesWebbSin1 (stress-activated protein kinase (SAPK)-interacting protein 1, MAPKAP1) is an essential component of the Torc2 complex. mTORC2 is comprised of mTOR, a large … great lawyers in the worldWebb21 mars 2024 · This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding … greatldWebb6 okt. 2006 · (B) SIN1 is required for multiple growth factor-mediated Akt-Ser473 phosphorylation independent of nutrient input. Wild-type or SIN1 −/− MEFs were starved of serum and by nutrient (in PBS for the last 90 min) and then restimulated as indicated. p-Akt Ser473, p-Akt Thr308, total Akt, p-ERK1/2, and tubulin were determined by immunoblotting. flogas burtonWebb31 jan. 2024 · As shown in our previous study, Sin1 is specifically required for bone marrow B cell development via the Akt-mediated phosphorylation of FoxO1 to inhibit IL-7 … great laxey mine railway