Simon's two-stage design
Webb28 juli 2024 · Among the candidate two-stage designs, the Simon’s (1986) minimax design has the smallest maximal sample size n and the optimal design has the smallest expected sample size under H0 : p = p0, EN(p0). Minimax Design vs. Optimal Design. When designing a two-stage phase II trial with input parameters (p0, p1, α∗, 1 - β∗), one often ... Webb2 juli 2024 · Simon's two-stage design and the admissible two-stage design have been commonly used in practice for single-arm phase II clinical trials when the primary …
Simon's two-stage design
Did you know?
Webb1 nov. 1996 · Multistage designs for phase II clinical trials proposed by Gehan, Fleming, Simon and Ensign are described and compared. Gehan's and Simon's designs have two stages, Fleming's designs... Webb3 juli 2013 · The Screened Selection Design involves first applying Simon’s two-stage design [ 3] in each of the two parallel experimental arms, which allows for initial determination of efficacy and early stopping for futility in any of the arms.
Webb21 okt. 2024 · The Simon two-stage approach involves two criteria, minimax and optimal, for selecting sample sizes and critical values for these two-stage designs. Usually, the … WebbOptimum Designs Simon (1989) defines two optimum designs. The first is the minimax design which is the design with the smallest N that obeys both error rate constraints. …
WebbSimon's Two-Stage design This program generates Simon's optimal two-stage designs (Simon, 1989) and admissible designs from Jung et al. (2004) for Phase II single arm … Webb2.2. Study Design This is a Phase 2a, single arm study in subjects with moderate to severe UC. All subjects will receive 500 mg of PF-06480605 intravenously every 2 weeks (Q2W) for a total of 7 doses. The Simon’s two-stage design is …
Webb15 apr. 2024 · Simon R (1989). Optimal two-stage designs for phase II clinical trials, Controlled Clinical Trials 10: 1-10. ...
WebbThe Simon two-stage optimal design is often used for phase II cancer clinical trials. A study proceeds to the second stage unless the null hypothesis, that the true tumour response rate is below some specified value, is already accepted at the end of stage one. greencore purposegreencore privacy policyWebb7 mars 2024 · Simon R. (1989). Optimal Two-Stage Designs for Phase II Clinical Trials. Controlled Clinical Trials 10, 1-10. Jung SH, Carey M and Kim KM. (2001). Graphical Search for Two-Stage Designs for Phase II Clinical Trials. Controlled Clinical Trials 22, 367-372. See Also. twostage.inference, oc.twostage.bdry. greencore ready mealsWebb27 maj 2024 · For adaptive phase II clinical trials with binary endpoint, the Simon's two stage design is well-known (Simon 1989) and easy to implement. However, I was wondering, whether there are multi-arm two-stage extensions to this design and if there exist any implementations in statistical software packages (preferably in R)? greencore recruitment agencyWebbOptimal Two-Stage Designs For Phase II Clinical Trials Richard Simon, Controlled Clinical Trials 10:1-10, 1989. Enter probability of accepting poor drug (alpha) [between 0 and 0.3 only] Enter probability of rejecting good ... flowtrixWebb1 juli 2024 · Compared with the Gehan two-stage design, the Simon two-stage design has the advantage of being able to determine an early termination of trials when no or low anti-tumor activities are... greencore resources limitedhttp://www.cancer.unc.edu/biostatistics/program/ivanova/SimonsTwoStageDesign.aspx greencore resources limited hong kong