Tīmeklis2024. gada 13. nov. · Of note, in those cell lines that were responsive to daratumumab in CDC assays (>50% tumor cell lysis), CDC activity of HexaBody-CD38 was superior to daratumumab, with IC50 values for HexaBody-CD38 2.4- to 13-fold lower than for daratumumab. Moreover, HexaBody-CD38 unlocked CDC activity in 17 out of 28 … Tīmeklismab induced both CDC and ADCC in vitro effectively, and there is a significant association between Daratumumab-induced CDC/ADCC and the expression level of …
CD38 expression enhances sensitivity of lymphoma T and B cell …
Tīmeklis2006. gada 1. sept. · CD38 has been widely characterised both as an ectoenzyme and as a receptor. In the present paper, we investigated the role of CD38 as possible … TīmeklisIt bound to the antigen CD38 on a dose-dependent manner both by ELISA (Fig. 1a) and flow cytometry in Raji cells (Fig. 1b and c); meanwhile, 3G3 showed satisfactory cytotoxicity function on a dose ... bob\\u0027s discount recliner chairs
SAR650984: A Potent Anti-CD38 Therapeutic Antibody with Three ...
Tīmeklis2008. gada 25. janv. · Top, differential CDC in Raji clones (A) and primary B-CLL cells (B). Parental, CD52 low, and CD52 high Raji cell clones and B-CLL cells were … TīmeklisNational Center for Biotechnology Information Tīmeklis2024. gada 28. apr. · In addition, introduction of the E430G mutation unlocked CDC activity of the CD37 mAbs in Raji cells (EC 50 ranging from 0.29 to 0.77 µg/ml), … bob\\u0027s discount recliner chairs electric