A degron is a portion of a protein that is important in regulation of protein degradation rates. Known degrons include short amino acid sequences, structural motifs and exposed amino acids (often Lysine or Arginine ) located anywhere in the protein. In fact, some proteins can even contain multiple degrons. Degrons are present in a variety of organisms, from the N-degrons (see N … WebAug 13, 2008 · Phosphodegron recognition by SCF Cdc4. F-box proteins (FBPs) are the substrate-specificity subunits of the multisubunit SCF family of E3 ligases, which contains …
Global analysis of phosphorylation and ubiquitylation cross
http://endo.dxy.cn/article/62891 Web(Cdc4) phosphodegron (CPD), a consensus motif for ubiquity-lation by Fbw7, which includes Thr176. Ectopic expression of Fbw7 destabilized GATA2 and promoted its proteasomal deg-radation. Substitution of threonine 176 to alanine in GATA2 inhibitedbindingwithFbw7,andtheubiquitylationanddegra-dation of GATA2 by Fbw7 was … binghamton directory
Cell Death & Differentiation:磷酸化依赖的泛素降解底物研究中取 …
WebJul 12, 2024 · 通常而言,SCF通过识别底物蛋白上被磷酸化修饰后的特定结构域(也称作磷酸化降解结构域,“phosphodegron”),从而泛素化底物后进行降解。 WebJul 7, 2012 · TAZ contains another phosphodegron in its N-terminal region that also matches the β-TrCP recognition sequence DSGXXS and is adjacent to the LATS phosphorylation site Ser-66 (Fig. 3 B). Phosphorylation of Ser-66 by LATS could provide the priming phosphorylation for subsequent phosphorylation of Ser-62 and Ser-58 by GSK3β … WebMar 18, 2024 · The phosphodegron (S478) and FASP priming sites (S659) are phosphorylated quite slowly. The relative rates of priming site and phosphodegron site phosphorylation are influenced by the carboxy-terminus of CK1δ/ε, controlling the phosphoswitch. Phosphorylation at the S478 phosphodegron site drives β-TrCP … binghamton dorm prices