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WebApr 13, 2024 · The SNX31 c.963delG point mutation mouse model (SNX31m/m) was constructed using CRISPR/Cas9 technology. At 2-4 months of age, SNX31m/m mice showed fundus phenotypes similar to FEVR-like changes, including vascular leakage and retinal atrophy. Moreover, we found that VEGF and apoptotic pathways were involved in these … WebSep 20, 2024 · INTRODUCTION. In an effort to generate and share GWAS summary statistics from the 500K UK Biobank release to the scientific community, we faced a set of practical challenges in efficiently running GWAS analyses on such a large scale in order to quickly provide association results that may inform variant interpretation and downstream … WebApr 16, 2024 · We conducted a genome-wide association study testing the effect of 7,666,894 variants on three depression phenotypes (broad depression, probable MDD and ICD-coded MDD) using up to 322,580 UK Biobank participants. Broad depression was based on self-reported help-seeking behaviour for mental health difficulties from either a general … henry stickman download free