Irf1 macrophage
WebFeb 2, 2024 · IRF1 is a 325-amino acid transcription factor composed of an amino-terminal DNA-binding domain (DBD) that can bind to DNA interferon-stimulated response elements (ISRE) or positive regulatory domain I (PRDI) motifs, 58 an intermediate segment containing a putative nuclear localization sequence (NLS), and a C-terminal IRF association domain 2 … WebJul 27, 2024 · In this study, we found that hypoxic lung cancer cells promoted macrophage M2 polarization by secreting exosome transfer excessive miR-21. MiR-21 targeted binding the 3′UTR of interferon-regulatory factors 1 (IRF1) and downregulated the expression of IRF1 in macrophage. The polarized M2 macrophages further promoted lung cancer cell …
Irf1 macrophage
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WebApr 14, 2011 · Interferon regulatory factors (IRFs) are a family of transcription factors comprised of nine members (IRF1-9) in mammalian cells. IRF10 has only been identified in avian species; its DNA homolog... WebApr 23, 2024 · Our data suggest that the BET inhibitor JQ1 can modulate the inflammatory response and migration through the regulation of LPS-induced IRF1 in human microglia. Introduction Microglia are...
WebIn accordance, we observed that the isoform Gm12216-201 was responsible for the strongest induction of Irf1 transcription in a macrophage cell line RAW264.7 … WebSep 1, 2024 · (E) IRF1 binding to the CIIta promoter at 4 h was not affected by SfA. Macrophages were incubated for 1 h with medium or SfA and then IFN-γ was added for 4 h, and the in vivo binding of IRF1 to CIIta promoter IV was determined by chromatin immunoprecipitation. Each graph represents mean ± SD of three independent experiments.
WebMay 4, 2024 · To confirm that the STAT1/IRF1 signal pathway regulated by miR-19a-3p plays an important role in M1 macrophage polarization in LPS challenged sepsis model. Male … WebHowever, only CD36hi macrophages were primed for Activin A expression, via the activity of IRF1. Our results provide insight into the heterogeneity of human lymphoid organ macrophages and show that tonsil CD36hi macrophage specialization is the result of both intrinsic features and interaction with stromal cells.
WebApr 6, 2024 · Using KMeC and LMeC cells, we studied IRF1 expression in rNDV-infected cells. The results showed that the expression of IRF genes increased in lymphocytes co-cultured with cells infected with rNDV-cIFNγ, which suggested that cIFNγ produced after recombinant virus infection acts on surrounding lymphocytes and promotes the …
WebMar 16, 2008 · In addition, IRF1 regulates the induction of inducible nitric oxide synthase and the interleukin 12 p35 subunit (IL-12p35) in macrophages and has been linked to the pathogenesis of autoimmune ... cseinhouseWebIn accordance, we observed that the isoform Gm12216-201 was responsible for the strongest induction of Irf1 transcription in a macrophage cell line RAW264.7 (Supplementary information, Fig. S11c). cse infodisWebNov 26, 2024 · IRF1 is required for the induction of Mda5 in macrophages. a In vivo binding of IRF1 to the Mda5 promoter was analyzed by ChIP assays. Macrophages were treated for 3 h with IFN-α or LPS ( n = 4). b BMDMs were transfected with either an siRNA directed against Irf1 or a control siRNA against GFP . cse ingenicoWebIRF1 is also involved in LPS-induced oxidative stress outcomes in macrophages, thus contributing to endotoxemia [3]. Of note, it has been proposed that LPS-mediated IRF1 expression in macrophages controls … dyson v6 battery screw sizeWebPolarized macrophages can be broadly classified into classically activated macrophages (M1) and alternatively activated macrophages (M2) in response to the microenvironment signals. Interferon regulatory factor 1 (IRF1) has been demonstrated to play a critical role in macrophage polarization. cse ingelianceWebFeb 2, 2024 · Human IRF1 is essential for IFN-γ-dependent macrophagic immunity to mycobacteria, but largely redundant for IFN-α/β-dependent antiviral immunity. Discover the world's research 20+ million members... cse ing mopWebMar 23, 2024 · IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility - ScienceDirect Volume 34, Issue 12, 23 March 2024, 108891 Article IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by … dyson v6 battery won\u0027t charge