Gcn5-related n-acetyltransferase gnat
WebGeneral control non-repressible 5 (GCN5)-related N-acetyltransferases (GNAT) catalyze the transfer of an acyl moiety from acyl coenzyme A (acyl-CoA) to a diverse group of substrates and are widely distributed in all … Web(1 of 1) PTHR13355//PTHR13355:SF12 - GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE // GCN5-RELATED N-ACETYLTRANSFERASE (GNAT) FAMILY PROTEIN: C. reinhardtii v5.6: 5872 chromosome_10: 6192621-6198492: 1 Member Protein Name Organism Name ...
Gcn5-related n-acetyltransferase gnat
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WebJan 5, 2024 · From the result, the ShKAT enzyme belongs to the GNAT (general control non-repressible 5 (GCN5)-related N-acetyltransferases) superfamily and shares relatively high sequence similarity with N-acetyltransferases from Jeotgalicoccus coquinae (66%, NCBI Reference Sequence: WP_184281624.1), Jeotgalicoccus sp. ATCC 8456 (65%, …
WebMar 4, 2024 · PAC adopts a fold consistent with the GCN5-related N-acetyltransferase (GNAT) family (Fig. 1a-b and Supplementary Fig. S2), consisting of a seven-stranded β-sheet interspersed with four α ... WebFeb 1, 2024 · Gcn5 serves as the defining member of the Gcn5-related N-acetyltransferase (GNAT) superfamily of proteins that display a common structural fold and catalytic mechanism involving the transfer of the acyl-group, primarily acetyl-, from CoA to an acceptor nucleophile.In the case of Gcn5, the target is the ε-amino group of lysine …
To determine the crystallographic structure of an uncharacterized GNAT from E. anophelis and allow the identification of key motifs and structural hallmarks common to GNAT family members, we first cloned the gene and recombinantly expressed the protein as a 6-His fusion (see “Materials and methods”). Following … See more Our structure contained a well-ordered acetyl-CoA molecule bound in the active site (Fig. 3AB). The interface between acetyl-CoA buries 593 Å2 of surface area and mediated by 10 hydrogen bonds. Key residues involved in … See more GNATs adopt a wide variety of assemblies, ranging from monomers, dimers, trimers, tetramers, hexamers, and dodecameric (double … See more WebJan 27, 2016 · The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that includes more than 100000 members among eukaryotes and prokaryotes. Acetylation appears as a major regulatory post-translational modification and is as widespread as phosphorylation. N-Acetyltransferases transfer an acetyl group from …
WebMar 17, 2024 · The chloroplast acetylation machinery in Arabidopsis thaliana consists of eight General control non-repressible 5 (GCN5)-related N-acetyltransferase (GNAT)–family enzymes that catalyze both N-terminal and lysine acetylation of proteins. Additionally, two plastid GNATs have also been reported to be involved in the …
WebGcn5 serves as the defining member of the Gcn5-related N-acetyltransferase (GNAT) superfamily of proteins that display a common structural fold and catalytic mechanism … chartridge hotelWebStructural Characterization of a Gcn5-Related N-Acetyltransferase from Staphylococcus aureus. The study provides the first high resolution structure of this GNAT enzyme from Staphyloccocus aureus, providing a strong platform for substrate and cofactor modelling, and structural/functional comparisons within this diverse enzyme superfamily. cursed ibukiWebSpermidine N-acetyltransferase (SpeG) prevents bacterial polyamine toxicity. The dodecameric three-dimensional structure of SpeG revealed an unknown polyamine allosteric site. SpeG acetylates spermidine/spermine using a … cursed icarly images