WebCYR61 is cysteine rich angiogenic inducer 61, also known as CCN1 is a 40-45 kDa signaling protein associated with the extracellular matrix. It regulates cellular proliferation, apoptosis, differentiation, migration, and adhesion through its interactions with different integrin receptors and through its heparin binding activity. Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of … See more CYR61 was first identified as a protein encoded by a serum-inducible gene in mouse fibroblasts. Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein). … See more Structural domains Full-length CYR61 protein contains 381 amino acids with an N-terminal secretory signal peptide followed by four structurally distinct domains. … See more CYR61 is highly expressed at sites of inflammation and wound repair, and is associated with diseases involving chronic inflammation and tissue injury. Wound healing and … See more CYR61 is located at human chromosome 1p22.3, whereas the mouse Cyr61 gene is located at chromosome 3, 72.9cM. The mouse CYR61 coding region spans ~3.2 Kb, containing 5 exons interspaced with 4 introns. The first exon encodes 5’-UTR sequence and the … See more During embryo development in mice, Cyr61 is highly expressed in the cardiovascular, skeletal, and neuronal systems. Cyr61 See more
Cyr61/CTGF/Nov family proteins in gastric carcinogenesis
WebAs internal control of TEADi activity, we used the cysteine-rich angiogenic inducer 61 (CYR61) biomarker, which shows modulation alone or combined with adagrasib ( Figure 4B and Supplementary ... WebJun 29, 2012 · CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix … slow readprocessor
Cysteine-rich, angiogenic inducer, 61 expression in patients with ...
WebRat CYR61(Cysteine-rich angiogenic inducer 61) ELISA Kit from XpressBio. Be the first to write a review! Citations: Supplier Page. Supplier Page from XpressBio for Rat … WebThe matri-cellular proteins 'cysteine-rich, angiogenic-inducer, 61' and 'connective tissue growth factor' are regulated in experimentally-induced sepsis with multiple organ … WebMar 4, 2014 · Cysteine‑rich angiogenic inducer 61 (CCN1/Cyr61) is a prompt response transcription product activated by growth factors. As a member of the CCN family, it … slow reading strategies